| 英文摘要 |
Cancers of the skin and lung induced by inorganic arsenic has been well recognized by the International Agency for Research on Cancer (IARC). The association between long-term inorganic arsenic exposure and cancers had been reported in many studies carried out in Taiwan. In order to reprove the carcinogenic effect of ingested inorganic arsenic, Chiaoshi, Chuangwei, Tungshan and Wuchien townships in Ilan County, where the arsenic level in well water is highly variable were selected as study area. This is the first study to assess the dose-response relationship between cancer risks and long-term individual exposure to inorganic arsenic.Our study also found that both arsenic exposure and cigarette smoking have a significantly synergistic effect on risks of cancers from lung and urinary among study subjects. ICP-AES was used to look into the content of elements in well water. We didn't find any elements in well water that significantly correlated to the carcinogenic ability of arsenic.Our large cohort study indicates that long-term exposure to inorganic arsenic based on more precise estimation of individual exposure among study subjects will increase risks of various cancer sites. |
