The purpose of this study was to explore the relationships between life adaptation, social support, and depression, respectively, for immigrated Vietnamese women living in Mei-nong town, Kaohsiung county. With a cross-section design, 143 participants were recruited by the purposive sampling. The structured questionnaires including Demographic Inventory Scale, Life Adaptation Scale, Social Support Scale, and Beck Depression Inventory Scale. Data were analyzed with t-test, One-way ANOVA, and multiple regression.