| 英文摘要 |
24ξ-methylcholestane-3β,5α,6β,25-tetrol-25-monoacetate (1), 24ξ-methyl
cholestane-3β,5α,6β,25-tetrol (2), 24ξ-methylcholestane-1β,3β,5α,6β,25-
pentol -25-monoacetate (3), (20S)-21-decanoxyl-24ξ-methylcholestane-3β,5α,6β,24 -
tetrol (4), (20S)-21,24-diacetaoxy-24ξ-methylcholestane-3β,5α,6β-triol (5) were isolated from the soft coral Sarcopyton glaucum which were collected from the Green island. The structures of 1~5 were established by spectroscopic data , compound 1~3 have been reported previously, compound 4 and 5 are new metabolites.
The cytotoxicity of compounds 1~5 against A-549, HT-29 and P388 cancer cell lines was studied. Only compound 1 showed significant cytotoxicity against the growth of HT-29 cells line. Compound 2~5 were found to be inactive against the above three cancer cells lines. |
