In our continuing study on the chemical constituents of Taiwanese soft corals, the EtOAc extracts of a gorgonian coral Isis hippuris and a alcyonarian coral Sinularia gibberosa were investigated, respectively. Seven compounds, including 3α,11β-dihydroxy-24-methyl-22,25epoxy-5α- furostan-18,20β-lactone (1), 3-acetyl-2-deacetyl-22R-hippurin-1 (2), hippuristerone F (3), hippurin-1 (4), 22-epi-hippurin-1 (5), 3-acetyl-2- desacetyl-22-epi-hippurin-1 (6) and 2-desacetyl-22-epi-hippurin-1 (7) were isolated from I. hippuris. Three metabolites, 3β,11-dihydroxy-24- methylene-9,11-secocholest-5-en-9-one (8), 3β,11-dihydroxy-24-methyl-9, 11-secocholest-5-en- 9-one (9) and 3β-hydroxy-11-acetoxy-24-methylene-9, 11-secocholest-5-en-9-one (10) were isolated from S. gibberosa. Among them, compounds 1–3, are new products. All metabolites 1–10 are steroids.
